Lack of in vitro biofilm formation does not attenuate the virulence of Streptococcus gordonii in experimental endocarditis

FEMS Immunol Med Microbiol. 2006 Dec;48(3):419-23. doi: 10.1111/j.1574-695X.2006.00168.x. Epub 2006 Nov 7.


The ability to induce experimental endocarditis of biofilm-deficient mutants of Streptococcus gordonii was studied in an isogenic background. Strains were inactivated in either comD, fruK or pbp2b genes, which are involved in biofilm formation. These strains were clearly impaired (>75% reduction) in biofilm production in vitro. However, this did not result in a decreased severity of infection in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bacterial Adhesion / genetics
  • Bacterial Adhesion / physiology
  • Biofilms / growth & development*
  • Disease Models, Animal
  • Endocarditis, Bacterial / microbiology*
  • Female
  • Rats
  • Streptococcal Infections / microbiology*
  • Streptococcus / genetics
  • Streptococcus / pathogenicity*
  • Virulence / genetics
  • Virulence / physiology*