Arc/Arg3.1: linking gene expression to synaptic plasticity and memory

Neuron. 2006 Nov 9;52(3):403-7. doi: 10.1016/j.neuron.2006.10.016.


Arc/Arg3.1 is an effector immediate-early gene implicated in the consolidation of memories. Although cloned a decade ago, the physiological role of Arc/Arg3.1 in the brain has remained elusive. Four papers in this issue of Neuron address this function. These studies show that Arc/Arg3.1 regulates endophilin 3 and dynamin 2, two components of the endocytosis machinery. Genetic ablation of Arc/Arg3.1 in mice or overexpression in culture suggest that Arc/Arg3.1 regulates AMPA receptor trafficking and synaptic plasticity. Finally, Arc/Arg3.1 knockout mice show memory retention deficits. These recent developments provide new insights into the function of this popular activity-dependent neuronal marker.

Publication types

  • Review

MeSH terms

  • Animals
  • Cytoskeletal Proteins / physiology*
  • Gene Expression / physiology*
  • Memory / physiology*
  • Nerve Tissue Proteins / physiology*
  • Neuronal Plasticity / physiology*


  • Cytoskeletal Proteins
  • Nerve Tissue Proteins
  • activity regulated cytoskeletal-associated protein