Cellular recognition of Mycobacterium tuberculosis ESAT-6 and KatG peptides in systemic sarcoidosis

Infect Immun. 2007 Jan;75(1):527-30. doi: 10.1128/IAI.00732-06. Epub 2006 Nov 6.

Abstract

Sarcoidosis is an enigmatic disease with a pathology similar to that of tuberculosis. We detected Th-1 immune responses to Mycobacterium tuberculosis ESAT-6 and KatG peptides from peripheral blood mononuclear cells from 15/26 sarcoidosis, 1/24 purified-protein-derivative-negative (PPD-) (P < 0.0001, Fisher's exact test), and 7/8 PPD-positive (PPD+) subjects (P = 0.21). This finding provides immunologic links between mycobacteria and systemic sarcoidosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antigens, Bacterial / immunology*
  • Bacterial Proteins / immunology*
  • Catalase / immunology*
  • Female
  • Humans
  • Leukocytes, Mononuclear / immunology
  • Male
  • Middle Aged
  • Mycobacterium tuberculosis / immunology
  • Sarcoidosis / complications*
  • Sarcoidosis / immunology
  • T-Lymphocytes / immunology
  • Tuberculin / immunology
  • Tuberculosis / complications*
  • Tuberculosis / immunology

Substances

  • Antigens, Bacterial
  • Bacterial Proteins
  • ESAT-6 protein, Mycobacterium tuberculosis
  • Tuberculin
  • Catalase
  • katG protein, Mycobacterium tuberculosis