Group B Streptococcus: global incidence and vaccine development

Nat Rev Microbiol. 2006 Dec;4(12):932-42. doi: 10.1038/nrmicro1552. Epub 2006 Nov 6.


An ongoing public health challenge is to develop vaccines that are effective against infectious diseases that have global relevance. Vaccines against serotypes of group B Streptococcus (GBS) that are prevalent in the United States and Europe are not optimally efficacious against serotypes common to other parts of the world. New technologies and innovative approaches are being used to identify GBS antigens that overcome serotype-specificity and that could form the basis of a globally effective vaccine against this opportunistic pathogen. This Review highlights efforts towards this goal and describes a template that can be followed to develop vaccines against other bacterial pathogens.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacterial Capsules / immunology
  • Bacterial Proteins / immunology
  • Bacterial Vaccines* / immunology
  • Female
  • Gene Expression Regulation, Bacterial / immunology
  • Genome, Bacterial / immunology
  • Global Health*
  • Humans
  • Incidence
  • Infant, Newborn
  • Polysaccharides, Bacterial / immunology
  • Pregnancy
  • Pregnancy Complications, Infectious / epidemiology
  • Pregnancy Complications, Infectious / prevention & control
  • Proteomics
  • Streptococcal Infections / epidemiology*
  • Streptococcal Infections / prevention & control*
  • Streptococcus agalactiae / genetics
  • Streptococcus agalactiae / immunology*
  • Streptococcus agalactiae / pathogenicity


  • Bacterial Proteins
  • Bacterial Vaccines
  • Polysaccharides, Bacterial