Reproducibility of quantitative estimate of magnetocardiographic ventricular depolarization and repolarization parameters in healthy subjects and patients with coronary artery disease

Ann Biomed Eng. 2007 Jan;35(1):59-68. doi: 10.1007/s10439-006-9210-9. Epub 2006 Nov 7.


Magnetocardiography (MCG) has been introduced as an innovative non-invasive diagnostic tool to identify various heart diseases. However, there have been little data on the reliability of MCG parameters. The purpose of this study is to examine the test-retest reliability of different diagnostic parameters derived from MCG. We investigated short-, intermediate-, and long-term reliability of nine parameters from T (max/3)-T (max) interval, and five parameters from each time point such as QRS-wave, the peak of R-, and T-wave were evaluated. Short-term reliability was tested in the youngest 20 subjects (mean age = 26.3 +/- 4.9 years) in three sessions separated by 5 min. Intermediate-term reliability was tested in the 35 subjects with coronary artery disease (CAD) (65.1 +/- 7.1 years) with two recording sessions each in the morning and afternoon, separated by more than four hours. Long-term reliability was tested in seven subjects (37.1 +/- 8.8 years) using seven daily sessions. Interclass correlation coefficients (ICC) showed that test-retest reliability was good to excellent (0.99 > or = ICC > or = 0.80) for six out of nine parameters within T (max/3)-T (max). In addition, all parameters on the peak of R-wave, T-wave, and QRS-wave integrated were good to excellent (0.99 > or = ICC > or = 0.80) except for one parameter of CAD patients showing lower ICC values under 0.7. In conclusion, our study showed that the test-retest characteristics of the studied MCG parameters are generally stable and reliable over periods of minutes to days in subjects with different age spectrums.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Coronary Artery Disease / diagnosis*
  • Coronary Artery Disease / physiopathology*
  • Diagnosis, Computer-Assisted / methods*
  • Heart Conduction System / physiopathology*
  • Heart Ventricles / physiopathology*
  • Humans
  • Magnetocardiography / methods*
  • Male
  • Reproducibility of Results
  • Sensitivity and Specificity