Abstract
Chemical exploration of Camchaya calcarea (family Compositae) has led to the isolation of nine known sesquiterpene lactones 1 - 9, together with caffeic acid methyl ester 10. Sesquiterpenes 1, 2, 3, 4, 5, 7, and 8 exhibited moderate antiplasmodial activity, but showed potent antimycobacterial activity. Interestingly, the cytotoxicity of sesquiterpene lactones 1, 2, and 4 towards small-cell lung cancer cell line (NCI-H187) is stronger (two orders of magnitude) than towards the Vero cell line. Caffeic acid methyl ester (10) was cytotoxic against NCI-H187 and BC cell lines, however the ester 10 showed only mild antimycobacterial activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / administration & dosage
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Antimalarials / pharmacology*
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Antimalarials / therapeutic use
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Antineoplastic Agents, Phytogenic / administration & dosage
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Antineoplastic Agents, Phytogenic / pharmacology*
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Antineoplastic Agents, Phytogenic / therapeutic use
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Antitubercular Agents / administration & dosage
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Antitubercular Agents / pharmacology
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Antitubercular Agents / therapeutic use
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Asteraceae*
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Cell Line, Tumor / drug effects
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Inhibitory Concentration 50
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Microbial Sensitivity Tests
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Mycobacterium tuberculosis / drug effects
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Parasitic Sensitivity Tests
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Phytotherapy*
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Plant Components, Aerial
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Plasmodium falciparum / drug effects*
Substances
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Antimalarials
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Antineoplastic Agents, Phytogenic
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Antitubercular Agents
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Plant Extracts