Preclinical imaging of mammary intraepithelial neoplasia with positron emission tomography

J Mammary Gland Biol Neoplasia. 2006 Apr;11(2):137-49. doi: 10.1007/s10911-006-9020-6.


Small-animal imaging with positron emission tomography (PET) has become a valuable tool for evaluating preclinical models of breast cancer and other diseases. In this review, we examine a number of issues related to preclinical imaging studies with PET, using transgenic models of ductal carcinoma in situ and metastasis as specific examples. We discuss imaging components such as reconstruction, normalization, and extraction of quantitative parameters. We also analyze the effect of longitudinal correlations on cohort size and present some simple statistical techniques for determining cohort sizes that may be helpful in designing preclinical imaging studies. We describe studies that are greatly facilitated by access to non-invasive imaging data including a study involving multiple endpoints and another investigating metastasis. We conclude with a brief survey of emerging approaches in small-animal PET imaging.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Carcinoma in Situ / diagnostic imaging*
  • Carcinoma, Ductal, Breast / diagnostic imaging*
  • Carcinoma, Ductal, Breast / secondary*
  • Disease Models, Animal
  • Disease Progression
  • Fluorodeoxyglucose F18*
  • Longitudinal Studies
  • Lymphatic Metastasis
  • Mammary Glands, Animal / diagnostic imaging
  • Mammary Glands, Animal / pathology
  • Mammary Neoplasms, Experimental / diagnostic imaging*
  • Mammary Neoplasms, Experimental / pathology
  • Mice
  • Positron-Emission Tomography / methods*
  • Positron-Emission Tomography / trends*
  • Whole-Body Counting / instrumentation
  • Whole-Body Counting / trends


  • Fluorodeoxyglucose F18