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, 72 (15), 1431-2

Free Radical-Scavenging Delta-Lactones From Boletus Calopus


Free Radical-Scavenging Delta-Lactones From Boletus Calopus

Jin-Woo Kim et al. Planta Med.


The methanol extracts from the fruiting body of the mushroom Boletus calopus showed free radical-scavenging activity. Bioactivity-guided fractionation of the methanol extracts led to a new hydroxylated calopin named calopin B, along with the known delta-lactones calopin and cyclocalopin A. The structure of the new calopin analogue was elucidated by spectroscopic methods. All compounds showed potent free radical-scavenging activity against superoxide, DPPH, and ABTS radicals with IC (50) values of 1.2 - 5.4 microg/mL.

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