Weight regain after slimming induced by an energy-restricted diet depends on interleukin-6 and peroxisome-proliferator-activated-receptor-gamma2 gene polymorphisms

Br J Nutr. 2006 Nov;96(5):965-72. doi: 10.1017/bjn20061901.


Weight-loss maintenance after following an energy-restricted diet is a major problem that a number of studies are trying to characterise. The aim of the present study was to investigate the role of IL-6 -174G>C and PPAR-gamma2 Pro12Ala variants on weight regulation in obese subjects receiving a low-energy diet and at 1 year after the acute slimming period. Sixty-seven volunteers (age 34.7 (SD 7.0) years; BMI 35.8 (SD 4.8) kg/m(2)) were enrolled in a 10-week dietary intervention and were contacted again 1 year after the end of this period. Body composition was measured at three times during the study. Also, PPAR-gamma2 Pro12Ala and IL-6 -174G>C polymorphisms were analysed in the participants. No statistical differences were observed depending on the genetic variants at baseline for anthropometric variables, or after the intervention. However, the C allele of the -174G>C IL-6 gene polymorphism was more frequently observed (P=0.032) in subjects with successful weight maintenance (<10 % weight regain). In fact, the C allele partially protected against weight regain (odds ratio 0.24; P=0.049), while the conjoint presence of both gene variants (C+ and Ala+) further improved the ability for weight maintenance (odds ratio 0.19; P=0.043). The present study demonstrates that the C allele of the -174G>C polymorphism gives protection against regain of weight lost. Moreover, the presence of the Ala allele of the PPARgamma-2 together with the C allele strengthens this protection. These findings support a role for these polymorphisms on weight regulation and suggest a synergetic effect of both variants on weight maintenance after following a diet to lose weight.

MeSH terms

  • Adult
  • Alleles
  • Biomarkers / analysis
  • Body Composition / genetics
  • C-Reactive Protein / analysis
  • Caloric Restriction / methods*
  • Female
  • Gene Frequency / genetics
  • Genotype
  • Humans
  • Interleukin-6 / blood
  • Interleukin-6 / genetics*
  • Leptin / blood
  • Male
  • Obesity / drug therapy*
  • Obesity / genetics
  • PPAR gamma / genetics*
  • Polymorphism, Genetic / genetics*
  • Weight Gain / genetics*
  • Weight Loss


  • Biomarkers
  • Interleukin-6
  • Leptin
  • PPAR gamma
  • C-Reactive Protein