The effect of halothane, isoflurane, sevoflurane and propofol infusion on renal function after coronary artery bypass surgery

Middle East J Anaesthesiol. 2006 Jun;18(5):955-64.


Renal insufficiency after cardiac surgery is associated with increased mortality, morbidity, and length of stay in the intensive care unit. We investigated the effect of isoflurane, halothane, sevoflurane and propofol anesthesia on perioperative renal function following elective coronary artery surgery. The medical records of 224 patients, in the Hacettepe University Medical Faculty Hospital who had undergone cardiac surgery in one year, were retrospectively reviewed. 65 (29%) patients received isoflurane, 68 (30%) patients received halothane, 64 (29%) patients received sevoflurane, and 27 (12%) patients received propofol infusion as part of maintenance anesthesia for coronary artery bypass surgery. Patient characteristics (age, sex, preoperative ejection fraction), operative data (duration of CPB, duration of operation, number of distal anastomoses, usage of diuretic, intraoperative crystalloid and blood transfusion), intraoperative urinary output, preoperative and postoperative (6th hours and 24th hours) BUN and plasma creatinine levels, were not statistically significant between and within groups. Intraoperative inotropic agent (dopamine) was used in 8 (12.3%) patients in the isoflurane group, in 10 (14.7%) patients in the halothane group, in 11 (17.2%) patients in sevoflurane group and in 9 (33.3%) patients in the propofol group. Postoperatively fluid and blood transfusion, postoperative drainage, urinary output, diuretic usage were smiliar between the four groups (p>0,05). Inotropic agent was used in 8 (12.3%) patients in the isoflurane group, in 9 (13.2%) patients in the halothane group, in 16 (25%) patients in the sevoflurane group and in 7 (25.9%) patients in the propofol group. It is concluded that, halothane, isoflurane, sevoflurane and propofol infusion anesthesia as part of anesthesia maintenance for elective coronary artery bypass surgery does not affect early postoperative renal functions.

MeSH terms

  • Aged
  • Analysis of Variance
  • Anesthetics, Inhalation / blood
  • Anesthetics, Inhalation / pharmacology
  • Anesthetics, Intravenous / blood
  • Anesthetics, Intravenous / pharmacology
  • Blood Urea Nitrogen
  • Coronary Artery Bypass / methods*
  • Creatinine / blood
  • Female
  • Halothane / blood
  • Halothane / pharmacology*
  • Humans
  • Infusions, Intravenous / methods
  • Isoflurane / blood
  • Isoflurane / pharmacology*
  • Kidney / drug effects*
  • Male
  • Methyl Ethers / blood
  • Methyl Ethers / pharmacology*
  • Middle Aged
  • Postoperative Complications / prevention & control
  • Propofol / blood
  • Propofol / pharmacology*
  • Renal Insufficiency / prevention & control*
  • Retrospective Studies
  • Sevoflurane
  • Urea / blood


  • Anesthetics, Inhalation
  • Anesthetics, Intravenous
  • Methyl Ethers
  • Sevoflurane
  • Urea
  • Creatinine
  • Isoflurane
  • Halothane
  • Propofol