A novel subunit of axonemal dynein conserved among lower and higher eukaryotes

FEBS Lett. 2006 Nov 27;580(27):6357-60. doi: 10.1016/j.febslet.2006.10.047. Epub 2006 Nov 10.


To elucidate the subunit composition of axonemal inner-arm dynein, we examined a 38 kDa protein (p38) co-purified with a Chlamydomonas inner arm subspecies, dynein d. We found it is a novel protein conserved among a variety of organisms with motile cilia and flagella. Immunoprecipitation using specific antibody verified its association with a heavy chain, actin and a previously identified light chain (p28). Unexpectedly, mutant axonemes lacking dynein d and other dyneins retained reduced amounts of p38. This finding suggests that p38 is involved in the docking of dynein d to specific loci.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algal Proteins / genetics*
  • Algal Proteins / metabolism
  • Animals
  • Chlamydomonas / genetics*
  • Chlamydomonas / metabolism
  • Cilia / genetics
  • Cilia / metabolism
  • Dyneins / genetics*
  • Dyneins / metabolism
  • Flagella / genetics
  • Flagella / metabolism
  • Protozoan Proteins / genetics*
  • Protozoan Proteins / metabolism


  • Algal Proteins
  • Protozoan Proteins
  • Dyneins