Laser assisted hatching in good prognosis patients undergoing in vitro fertilization-embryo transfer: a randomized controlled trial

Fertil Steril. 2007 Feb;87(2):283-7. doi: 10.1016/j.fertnstert.2006.07.1498. Epub 2006 Nov 13.

Abstract

Objective: To evaluate whether assisted hatching improves clinical outcomes of embryo transfers to good prognosis patients, defined as patients < or =39 years with normal follicle-stimulating hormone (FSH) and E(2) levels, no more than one previous unsuccessful cycle of in vitro fertilization (IVF)-embryo transfer, and good embryo quality.

Design: Prospective randomized controlled trial.

Setting: Private assisted reproductive technology (ART) center.

Patient(s): One hundred ninety-nine good prognosis patients undergoing IVF-embryo transfer.

Intervention(s): In vitro fertilization followed by embryo transfer on day 3 after oocyte retrieval with or without assisted hatching using a 1,480-nm wavelength infrared laser.

Main outcome measure(s): Clinical intrauterine pregnancy, spontaneous pregnancy loss, and live birth.

Result(s): Rates of clinical intrauterine pregnancy with fetal cardiac activity (53% vs. 54% per cycle), spontaneous pregnancy loss (13% vs. 16% per pregnancy), and live birth (47% vs. 46% per cycle) were very similar between treatment cycles with laser-assisted hatching and control cycles in which embryos were transferred without assisted hatching. There were no significant differences between treatment and control groups in any measured clinical outcome parameters.

Conclusion(s): Assisted hatching does not improve clinical outcomes among good prognosis patients.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Embryo Transfer / statistics & numerical data*
  • Female
  • Fertilization in Vitro / statistics & numerical data*
  • Humans
  • Infertility, Female / epidemiology*
  • Infertility, Female / therapy*
  • Laser Therapy*
  • Maryland / epidemiology
  • Microdissection / methods
  • Microdissection / statistics & numerical data*
  • Micromanipulation / methods
  • Micromanipulation / statistics & numerical data
  • Outcome Assessment, Health Care
  • Pregnancy
  • Pregnancy Outcome / epidemiology*
  • Prognosis
  • Treatment Outcome