Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Nov 15;58(11):1224-42.
doi: 10.1016/j.addr.2006.07.023. Epub 2006 Sep 16.

Non-viral Ocular Gene Therapy: Potential Ocular Therapeutic Avenues

Affiliations
Review

Non-viral Ocular Gene Therapy: Potential Ocular Therapeutic Avenues

C Bloquel et al. Adv Drug Deliv Rev. .

Abstract

Non-viral vectors for potential gene replacement and therapy have been developed in order to overcome the drawbacks of viral vectors. The diversity of non-viral vectors allows for a wide range of various products, flexibility of application, ease of use, low-cost of production and enhanced "genomic" safety. Using non-viral strategies, oligonucleotides (ODNs) can be delivered naked (less efficient) or entrapped in cationic lipids, polymers or peptides forming slow release delivery systems, which can be adapted according to the organ targeted and the therapy purposes. Tissue and cell internalization can be further enhanced by changing by physical or chemical means. Moreover, a specific vector can be selected according to disease course and intensity of manifestations fulfilling specific requirements such as the duration of drug release and its level along with cells and tissues specific targeting. From accumulating knowledge and experience, it appears that combination of several non-viral techniques may increase the efficacy and ensure the safety of these evolving and interesting gene therapy strategies.

Similar articles

See all similar articles

Cited by 20 articles

See all "Cited by" articles

LinkOut - more resources

Feedback