Leukemoid reaction in pancreatic cancer: a case report and review of the literature

JOP. 2006 Nov 10;7(6):631-4.


Context: The presentation of pancreatic cancer with a leukemoid reaction is rare with no prior reports in the English language literature.

Case report: We report a case of advanced pancreatic cancer presenting with leukemoid reaction. Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor levels were normal while interleukin-6 was elevated. The patient had no evidence of infection. The leukemoid reaction correlated with tumor response.

Conclusion: This is the first case report in the English literature of a leukemoid paraneoplastic syndrome in a patient with pancreatic cancer. A clear correlation between tumor response, serum carbohydrate antigen 19-9 levels and leukemoid reaction is documented.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adenocarcinoma / complications*
  • Adenocarcinoma / diagnosis*
  • Adenocarcinoma / diagnostic imaging
  • Humans
  • Leukemoid Reaction / complications*
  • Leukemoid Reaction / pathology
  • Male
  • Middle Aged
  • Neoplasm Metastasis / diagnosis
  • Neoplasm Metastasis / diagnostic imaging
  • Pancreatic Neoplasms / complications*
  • Pancreatic Neoplasms / diagnosis*
  • Pancreatic Neoplasms / diagnostic imaging
  • Radiography