Older adult medication compliance: integrated review of randomized controlled trials

Am J Health Behav. 2006 Nov-Dec;30(6):636-50. doi: 10.5555/ajhb.2006.30.6.636.


Objective: To examine interventions and outcomes of medication compliance studies in older adults.

Methods: An integrated review of randomized controlled trials was completed.

Results: Thirty-one of 57 studies reported significantly greater medication compliance in treatment subjects versus control subjects. Interventions included counseling, education, self-medication programs, cues and organizers, and decreasing dosing frequency. Decreasing dosing frequency and self-medication programs were successful, although not frequently evaluated.

Conclusions: Future studies should address methodologic flaws (eg, small sample sizes, measurement validity issues), test theory-based interventions delivered by diverse providers, evaluate intervention dose, and examine persistence of compliance behavior changes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aged
  • Aged, 80 and over
  • Drug Therapy*
  • Humans
  • Middle Aged
  • Patient Compliance*
  • Randomized Controlled Trials as Topic*