Breastfeeding enhances the antibody response to Hib and Pneumococcal serotype 6B and 14 after vaccination with conjugate vaccines

Vaccine. 2007 Feb 9;25(8):1497-502. doi: 10.1016/j.vaccine.2006.10.025. Epub 2006 Oct 30.


Background: This study was performed in order to investigate the relationship between breastfeeding and the antibody response after vaccination with conjugate vaccines against Hib and pneumococcal diseases.

Methods: This was an open non-randomised multi-centre study enrolling 101 healthy Swedish infants. PncCRM was administered concomitantly with DTaP/IPV/Hib at 3, 5, and 12 months at separate site. Duration of breastfeeding was calculated for days of almost exclusive as well as of total (any form of) breastfeeding.

Results: At 13 months of age 6 out of 83 children did not reach 0.2mug/ml against serotype 6B, and five of these were breastfed less than 90 days (Fisher's Exact test, P=0.011). Four children did not reach 1mug/ml against Hib and all those were breastfed less than 90 days (Fisher's Exact test, P=0.008). One month after the second dose, at 6 months of age, children breastfed 90 days or more showed significantly higher GMC against serotype 14 (P=0.003).

Conclusion: This study indicates that children exclusively breastfed 90 days or more might get a better serological protection against Hib, and the pneumococcal serotypes 6B and 14 after vaccination, compared to children less breastfed.

Publication types

  • Clinical Trial
  • Multicenter Study

MeSH terms

  • Antibodies, Bacterial / biosynthesis
  • Antibodies, Bacterial / blood
  • Breast Feeding*
  • Diphtheria-Tetanus-acellular Pertussis Vaccines / immunology
  • Haemophilus Infections / prevention & control*
  • Haemophilus Vaccines / immunology*
  • Heptavalent Pneumococcal Conjugate Vaccine
  • Humans
  • Infant
  • Meningococcal Vaccines / immunology
  • Milk, Human / immunology
  • Pneumococcal Vaccines / immunology*
  • Poliovirus Vaccine, Inactivated / immunology
  • Streptococcus pneumoniae / classification
  • Streptococcus pneumoniae / immunology*
  • Vaccines, Conjugate / immunology


  • Antibodies, Bacterial
  • Diphtheria-Tetanus-acellular Pertussis Vaccines
  • Haemophilus Vaccines
  • Heptavalent Pneumococcal Conjugate Vaccine
  • Meningococcal Vaccines
  • Pneumococcal Vaccines
  • Poliovirus Vaccine, Inactivated
  • Vaccines, Conjugate