Impact of influenza vaccination on major cause-specific mortality

Vaccine. 2007 Jan 26;25(7):1196-203. doi: 10.1016/j.vaccine.2006.10.015. Epub 2006 Oct 25.


The efficacy of influenza vaccination is not well understood for major cause-specific mortality except pneumonia. For 10 months we followed the mortality data of 35,637 vaccinated elderly (>65 years old) in a county with 102,698 elderly in southern Taiwan. A multivariate Cox model showed that vaccination was significantly associated with lower mortality for all causes, [hazards ratio (HR)=0.56], stroke (HR=0.35), renal disease (HR=0.40), diabetes mellitus (HR=0.45), pneumonia (HR=0.47), COPD (HR=0.55), malignancy (HR=0.74), and heart diseases (HR=0.78), p<0.05. Influenza vaccination was strongly associated with reducing major cause-specific mortality.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Analysis of Variance
  • Female
  • Humans
  • Influenza Vaccines / therapeutic use*
  • Influenza, Human / mortality*
  • Influenza, Human / prevention & control*
  • Male
  • Proportional Hazards Models
  • Risk Factors
  • Taiwan / epidemiology
  • Treatment Outcome
  • Vaccination / statistics & numerical data*


  • Influenza Vaccines