[Chromatin modifications during X-chromosome inactivation in female mammals]

Genetika. 2006 Sep;42(9):1225-34.
[Article in Russian]


In female mammals, the process of dosage compensation occurs during early embryonic development. As a result of this, one of X-chromosomes becomes transcriptionally inactive. This process is accompanied by chromatin remodeling on inactivated X-chromosome, providing transcriptional silencing of the genes and maintenance of their inactive state. In the present review, the dynamics of modifications occurring during embryonic inactivation, their distribution over the inactive X-chromosome, interaction, and the role in establishing and maintening the inactive state are discussed. As an illustration, modifications on the inactive X-chromosome of the Microtus common vole are presented.

Publication types

  • English Abstract
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Arvicolinae / genetics*
  • Chromatin / genetics*
  • Chromatin / metabolism
  • CpG Islands / genetics
  • DNA Methylation
  • DNA Replication Timing
  • Female
  • Genomic Imprinting
  • Histones / genetics
  • Histones / metabolism
  • Mice
  • X Chromosome Inactivation / genetics*


  • Chromatin
  • Histones