Abstract
We report the sequence of a complementary DNA (cDNA) that encodes the chicken GABAA receptor alpha 1 subunit, which is extremely homologous to mammalian alpha 1 subunits. The distribution of alpha 1 subunit transcripts is shown to correlate mainly, but not completely, with the previously-reported pattern of benzodiazepine type I (BZI) binding sites in the avian brain. These results suggest that the alpha 1 subunit may not necessarily be restricted to receptors having BZI pharmacology.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Autoradiography
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Base Sequence
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Brain / physiology*
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Chick Embryo
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DNA / genetics*
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Gene Library
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Macromolecular Substances
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Molecular Sequence Data
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Oligonucleotide Probes
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Poly A / genetics
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Poly A / isolation & purification
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RNA / genetics
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RNA / isolation & purification
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RNA, Messenger / analysis
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RNA, Messenger / genetics*
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Receptors, GABA-A / genetics*
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Sulfur Radioisotopes
Substances
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Macromolecular Substances
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Oligonucleotide Probes
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RNA, Messenger
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Receptors, GABA-A
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Sulfur Radioisotopes
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Poly A
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RNA
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DNA