The chicken GABAA receptor alpha 1 subunit: cDNA sequence and localization of the corresponding mRNA

Brain Res Mol Brain Res. 1991 Mar;9(4):333-9. doi: 10.1016/0169-328x(91)90081-8.

Abstract

We report the sequence of a complementary DNA (cDNA) that encodes the chicken GABAA receptor alpha 1 subunit, which is extremely homologous to mammalian alpha 1 subunits. The distribution of alpha 1 subunit transcripts is shown to correlate mainly, but not completely, with the previously-reported pattern of benzodiazepine type I (BZI) binding sites in the avian brain. These results suggest that the alpha 1 subunit may not necessarily be restricted to receptors having BZI pharmacology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Autoradiography
  • Base Sequence
  • Brain / physiology*
  • Chick Embryo
  • DNA / genetics*
  • Gene Library
  • Macromolecular Substances
  • Molecular Sequence Data
  • Oligonucleotide Probes
  • Poly A / genetics
  • Poly A / isolation & purification
  • RNA / genetics
  • RNA / isolation & purification
  • RNA, Messenger / analysis
  • RNA, Messenger / genetics*
  • Receptors, GABA-A / genetics*
  • Sulfur Radioisotopes

Substances

  • Macromolecular Substances
  • Oligonucleotide Probes
  • RNA, Messenger
  • Receptors, GABA-A
  • Sulfur Radioisotopes
  • Poly A
  • RNA
  • DNA

Associated data

  • GENBANK/X54244