Asymptomatic bacteriuria in women with diabetes mellitus: effect on renal function after 6 years of follow-up

Arch Intern Med. 2006 Nov 13;166(20):2222-7. doi: 10.1001/archinte.166.20.2222.


Background: The long-term consequences of asymptomatic bacteriuria (ASB) on renal function in women with diabetes mellitus (DM) are unknown.

Methods: A prospective study was performed among women with type 1 or type 2 DM. Women with ASB (diagnosis based on findings from 1 urine culture specimen) were compared with women without ASB for differences in renal function development and incidence of hypertension.

Results: A total of 644 women were included in the study (296 with type 1 DM and 348 with type 2 DM; mean [SD] age, 51 [15] years) and followed up for a mean (SD) duration of 6.1 (1.9) years. The prevalence of ASB was 17%. In women with DM and ASB, the creatinine clearance decreased from 87 mL/min (1.45 mL/s) at baseline to 76 mL/min (1.27 mL/s) at study end point; in women with DM without ASB the creatinine clearance decreased from 97 to 88 mL/min (from 1.62 to 1.47 mL/s). In the multivariate analyses, adjusted for age, length of follow-up, duration of DM, and microalbuminuria at baseline, no association was found between ASB and the relative or the absolute decrease in creatinine clearance; the same results were shown also when women with DM type 1 and women with DM type 2 were analyzed separately. Women with ASB developed hypertension more often than women without ASB (54% vs 37%; P = .045), but there was no significant association in the multivariate analysis (odds ratio, 1.5; 95% confidence interval, 0.7-3.6).

Conclusion: Women with DM (type 1 or type 2) with ASB do not have an increased risk for a faster decline in renal function or the development of hypertension after 6 years of follow-up.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Bacteriuria / complications*
  • Bacteriuria / epidemiology
  • Chi-Square Distribution
  • Diabetes Mellitus*
  • Female
  • Follow-Up Studies
  • Humans
  • Hypertension / epidemiology
  • Hypertension / etiology*
  • Kidney Diseases / epidemiology
  • Kidney Diseases / etiology*
  • Middle Aged
  • Netherlands / epidemiology
  • Prevalence
  • Regression Analysis
  • Risk Factors