Clinical characteristics of obesity-hypoventilation syndrome in Japan: a multi-center study

Intern Med. 2006;45(20):1121-5. doi: 10.2169/internalmedicine.45.1747. Epub 2006 Nov 15.


Objective: To clarify the prevalence and clinical characteristics of obesity-hypoventilation syndrome (OHS) in a large number of patients with moderate to severe obstructive sleep apnea syndrome (OSAS).

Methods: Subjects comprised 611 patients with OSAS registered from 7 sleep centers and clinics and analyzed according to the definitions of the Respiratory Failure Research Group of the Japanese Ministry of Health and Welfare. Baseline characteristics, polysomnographic data during sleep, laboratory blood examinations, excessive daytime sleepiness, pulmonary functions, and arterial blood gases were compared between OHS and non-OHS patients. Determinants of daytime hypercapnia were also examined in OHS patients.

Results: OHS was identified in 55 of the 611 patients with OSAS (9%). OHS patients were younger, heavier, and more somnolent than non-OHS patients and displayed more severe OSAS, liver dysfunctions, higher total cholesterol, and impaired pulmonary function. However, these differences were resolved except for pulmonary function after correction for obesity. Daytime hypercapnia was associated with impaired pulmonary function. Percent vital capacity (%VC) was most closely correlated with PaCO2 in OHS.

Conclusion: OHS patients display numerous abnormalities due to obesity compared with non-OHS patients. Impaired pulmonary function, particularly %VC, may play an important role in the development of daytime hypercapnia independent of obesity in OHS patients.

Publication types

  • Comparative Study
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alanine Transaminase / blood
  • Alkaline Phosphatase / blood
  • Aspartate Aminotransferases / blood
  • Body Mass Index
  • Carbon Dioxide / blood
  • Comorbidity
  • Female
  • Hematocrit
  • Humans
  • Hypercapnia / blood
  • Hypercapnia / epidemiology*
  • Hypercapnia / etiology
  • Hypercholesterolemia / epidemiology
  • Japan / epidemiology
  • Liver Diseases / blood
  • Liver Diseases / epidemiology
  • Male
  • Middle Aged
  • Obesity / complications
  • Obesity / epidemiology*
  • Obesity Hypoventilation Syndrome / complications
  • Obesity Hypoventilation Syndrome / epidemiology*
  • Obesity Hypoventilation Syndrome / pathology
  • Oxygen / blood
  • Partial Pressure
  • Polysomnography
  • Prevalence
  • Sleep Apnea, Obstructive / epidemiology
  • Spirometry
  • Vital Capacity*


  • Carbon Dioxide
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Alkaline Phosphatase
  • Oxygen