Acute disseminated encephalomyelitis associated with oral polio vaccine

Intern Med. 2006;45(20):1143-6. doi: 10.2169/internalmedicine.45.6029. Epub 2006 Nov 15.


A 27-year-old woman presented with acute paresis after taking an oral polio vaccine (OPV). Deep tendon reflexes were preserved, needle electromyography showed no neurogenic changes, and there were no lesions on spine magnetic resonance imaging (MRI), suggesting that motor neurons of the spinal cord were not affected. Brain MRI showed abnormal lesions in the tegmentum of the upper pons, left cerebral peduncles, truncus of the corpus callosum, and right parietal lobe. Cerebrospinal fluid revealed mild pleocytosis. The most probable diagnosis was acute disseminated encephalomyelitis associated with OPV.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Anti-Inflammatory Agents / therapeutic use
  • Brain / pathology
  • Cerebellum / pathology
  • Corpus Callosum / pathology
  • Diffusion Magnetic Resonance Imaging
  • Encephalomyelitis, Acute Disseminated / drug therapy
  • Encephalomyelitis, Acute Disseminated / etiology*
  • Encephalomyelitis, Acute Disseminated / pathology
  • Humans
  • Leukocytosis / etiology
  • Methylprednisolone / therapeutic use
  • Paresis / etiology*
  • Parietal Lobe / pathology
  • Poliovirus Vaccine, Oral / adverse effects*
  • Pons / pathology


  • Anti-Inflammatory Agents
  • Poliovirus Vaccine, Oral
  • Methylprednisolone