Cyclin D1 functions in cell migration

Cell Cycle. 2006 Nov 1;5(21):2440-2. doi: 10.4161/cc.5.21.3428. Epub 2006 Sep 22.

Abstract

Cell migration is essential for developmental morphogenesis, tissue repair, and tumor metastasis. A recent study reveals that cyclin D1 acts to promote cell migration by inhibiting Rho/ROCK signaling and expression of thrombospondin-1 (TSP-1), an extracellular matrix protein that regulates cell migration in many settings including cancer. Given the frequent overexpression of cyclin D1 in cancer cells, due to its upregulation by Ras, Rho, Src, and other genes that drive malignant development, the new findings suggest that cyclin D1 may have a central role in mediating invasion and metastasis of cancer cells by controlling Rho/ROCK signaling and matrix deposition of TSP-1.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle
  • Cell Movement*
  • Cyclin D1 / metabolism
  • Cyclin D1 / physiology*
  • Extracellular Matrix / metabolism
  • Fibroblasts / metabolism
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Neoplasms / metabolism
  • Protein-Serine-Threonine Kinases / metabolism
  • Retinoblastoma Protein / metabolism
  • Signal Transduction
  • Thrombospondin 1 / metabolism*
  • Transcription, Genetic
  • rho-Associated Kinases

Substances

  • Intracellular Signaling Peptides and Proteins
  • Retinoblastoma Protein
  • Thrombospondin 1
  • Cyclin D1
  • Protein-Serine-Threonine Kinases
  • rho-Associated Kinases