A causal role for the human tumor antigen preferentially expressed antigen of melanoma in cancer

Cancer Res. 2006 Nov 15;66(22):10639-42. doi: 10.1158/0008-5472.CAN-06-2522.


Tumor antigens are of interest as diagnostic and prognostic markers and potential therapeutic targets. The tumor antigen preferentially expressed antigen of melanoma (PRAME) is frequently overexpressed in a wide variety of cancers and is a prognostic marker for clinical outcome. It has been shown recently that PRAME functions as a repressor of retinoic acid signaling. Here, we discuss this novel insight in the context of the increasing interest in tumor antigens as targets for therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antigens, Neoplasm / biosynthesis
  • Antigens, Neoplasm / physiology*
  • Biomarkers, Tumor / biosynthesis
  • Humans
  • Neoplasms / immunology*


  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • PRAME protein, human