Impact of transporter-mediated drug absorption, distribution, elimination and drug interactions in antimicrobial chemotherapy

J Infect Chemother. 2006 Oct;12(5):241-50. doi: 10.1007/s10156-006-0478-3. Epub 2006 Nov 6.

Abstract

A comprehensive list of drug transporters has recently become available as a result of extensive genome analysis. Membrane transporters play important roles in determining the pharmacokinetic aspects of intestinal absorption, tissue distribution, and the urinary and biliary excretions of a wide variety of therapeutic drugs. The identification and characterization of transporters responsible for the transfer of nutrients and xenobiotics, including drugs, is expected to provide a scientific basis for understanding drug disposition, as well as the molecular mechanisms of drug-drug/drug-food/drug-protein interactions and inter-individual/inter-species differences. This review focuses on the influence of transporters on the pharmacokinetics of beta-lactam antibiotics, new quinolones, and other antimicrobial agents, as well as focusing on the drug-drug interactions associated with transporter-mediated uptake from the small intestine and transporter-mediated elimination from the kidney and liver.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Infective Agents / pharmacokinetics*
  • Anti-Infective Agents / pharmacology
  • Biological Transport
  • Drug Interactions
  • Humans
  • Intestinal Absorption
  • Membrane Transport Proteins / metabolism*
  • Quinolones / pharmacokinetics
  • Rifampin / pharmacokinetics
  • Tissue Distribution
  • beta-Lactams / pharmacokinetics

Substances

  • Anti-Infective Agents
  • Membrane Transport Proteins
  • Quinolones
  • beta-Lactams
  • Rifampin