Influence of Crocetin on experimental atherosclerosis in hyperlipidamic-diet quails

Eur J Pharmacol. 2007 Jan 12;554(2-3):191-5. doi: 10.1016/j.ejphar.2006.09.071. Epub 2006 Oct 19.

Abstract

Antioxidants have been expected to have potential as antiatherogenic agents. Crocetin is a natural carotenoid antioxidant isolated from Gardenia jasminoids Ellis. Therefore, in the present study, we investigated the inhibitory effect of Crocetin on experimental atherosclerosis in quails. The atherosclerosis model was established by feeding hyperlipidamic diet to quail and Crocetin (25, 50, 100 mg/kg/day) was administered by oral gavage. At the 9th week, serum lipids, malondialdehyde and nitric oxide were measured, and Hematoxylin-Eosin (H&E) stains was used to investigate the histopathological changes of aorta. Results showed that Crocetin could reduce the levels of serum total cholesterol, triglyceride, low density lipoprotein cholesterol and inhibit the formation of aortic plaque. Crocetin could also reduce malondialdehyde and inhibit the descending of nitric oxide in serum. The results suggested that Crocetin could inhibit the formation of atherosclerosis in quails, which might be related to the hypolipidemic effects along with the antioxidative properties of Crocetin.

MeSH terms

  • Animals
  • Antioxidants / administration & dosage
  • Antioxidants / pharmacology
  • Aorta / drug effects
  • Aorta / metabolism
  • Aorta / pathology
  • Atherosclerosis / blood
  • Atherosclerosis / chemically induced
  • Atherosclerosis / prevention & control*
  • Carotenoids / administration & dosage
  • Carotenoids / chemistry
  • Carotenoids / pharmacology*
  • Cholesterol / blood
  • Cholesterol, Dietary / administration & dosage
  • Cholesterol, Dietary / toxicity
  • Cholesterol, LDL / blood
  • Cholesterol, VLDL / blood
  • Diet, Atherogenic*
  • Dietary Fats / administration & dosage
  • Dietary Fats / toxicity
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Lipids / analysis
  • Lipids / blood
  • Male
  • Malondialdehyde / blood
  • Molecular Structure
  • Nitric Oxide / blood
  • Quail
  • Triglycerides / blood

Substances

  • Antioxidants
  • Cholesterol, Dietary
  • Cholesterol, LDL
  • Cholesterol, VLDL
  • Dietary Fats
  • Lipids
  • Triglycerides
  • crocetin
  • Nitric Oxide
  • Carotenoids
  • Malondialdehyde
  • Cholesterol