Fibulin-5 distribution in human eyes: relevance to age-related macular degeneration

Exp Eye Res. 2007 Feb;84(2):378-80. doi: 10.1016/j.exer.2006.09.021. Epub 2006 Nov 14.

Abstract

Fibulin-5 is an extracellular matrix glycoprotein that participates in elastogenesis. Mutations in the gene for fibulin-5 have been found to be associated with age-related macular degeneration. Little is known, however, about the expression of this gene in normal eyes or eyes with age-related macular degeneration. In this study, we evaluated the expression of the fibulin-5 protein in human donor eyes and localized this protein to Bruch's membrane and the intercapillary pillars of the choriocapillaris in normal eyes. In eyes with age-related macular degeneration, fibulin-5 was localized to pathologic basal deposits beneath the retinal pigment epithelium as well as some small drusen. These results suggest that fibulin-5 may promote extracellular deposit formation in macular degeneration.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bruch Membrane / metabolism
  • Calcium-Binding Proteins / metabolism*
  • Eye Proteins / metabolism*
  • Humans
  • Macular Degeneration / metabolism*

Substances

  • Calcium-Binding Proteins
  • Eye Proteins
  • fibulin