Gadolinium deposition in nephrogenic fibrosing dermopathy

J Am Acad Dermatol. 2007 Jan;56(1):27-30. doi: 10.1016/j.jaad.2006.10.048. Epub 2006 Nov 15.

Abstract

There is growing recognition of the association between the use of gadolinium-containing radiocontrast agents for magnetic resonance imaging and the serious dermal and systemic disease nephrogenic fibrosing dermopathy/nephrogenic systemic fibrosis (NFD/NSF). The pathogenesis of this entity remains unclear; however, our recent observations suggest a likely mechanism for the initial dermal manifestations of this gadolinium toxicity.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acidosis / complications
  • Aged
  • Blood Vessels / chemistry
  • Bone Marrow Cells / pathology
  • Calcium Phosphates / analysis
  • Contrast Media / adverse effects
  • Contrast Media / analysis*
  • Contrast Media / pharmacokinetics
  • Cyclosporine / adverse effects
  • Electron Probe Microanalysis
  • Female
  • Fibrosis
  • Gadolinium / adverse effects
  • Gadolinium / analysis*
  • Gadolinium / pharmacokinetics
  • Hepatitis C, Chronic / complications
  • Hepatitis C, Chronic / surgery
  • Humans
  • Hypocalcemia / complications
  • Kidney Failure, Chronic / chemically induced
  • Kidney Failure, Chronic / complications
  • Kidney Failure, Chronic / therapy
  • Liver Failure / complications
  • Liver Failure / surgery
  • Magnetic Resonance Imaging
  • Microscopy, Electron, Scanning
  • Models, Biological
  • Phosphates / blood
  • Postoperative Complications / etiology
  • Postoperative Complications / metabolism
  • Postoperative Complications / pathology
  • Renal Dialysis
  • Skin / blood supply
  • Skin / chemistry*
  • Skin / pathology
  • Skin Diseases / etiology
  • Skin Diseases / metabolism*
  • Skin Diseases / pathology

Substances

  • Calcium Phosphates
  • Contrast Media
  • Phosphates
  • Cyclosporine
  • calcium phosphate
  • Gadolinium