Lipoprotein particle analysis by nuclear magnetic resonance spectroscopy

Clin Lab Med. 2006 Dec;26(4):847-70. doi: 10.1016/j.cll.2006.07.006.


Laboratory measurements of plasma lipids (principally cholesterol and triglycerides) and lipoprotein lipids (principally low-density lipoprotein [LDL] and low-density lipoprotein [HDL] cholesterol) are the cornerstone of the clinical assessment and management of atherosclerotic cardiovascular disease (CVD) risk. LDL particles, and to a lesser extent very-low-density lipoprotein [VLDL] particles, cause atherosclerosis, whereas HDL particles prevent or reverse this process through reverse cholesterol transport. The overall risk for CVD depends on the balance between the "bad" LDL (and VLDL) and "good" HDL particles. Direct assessment of lipoprotein particle numbers us now possible through nuclear magnetic resonance spectroscopic analysis.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / blood
  • Cardiovascular Diseases / diagnosis
  • Cardiovascular Diseases / physiopathology
  • Cholesterol / blood*
  • Humans
  • Hyperlipoproteinemias / blood*
  • Hyperlipoproteinemias / classification
  • Lipoproteins / blood*
  • Magnetic Resonance Spectroscopy / methods*
  • Sensitivity and Specificity
  • Triglycerides / blood*


  • Lipoproteins
  • Triglycerides
  • Cholesterol