Cancer Metastasis: Building a Framework

Cell. 2006 Nov 17;127(4):679-95. doi: 10.1016/j.cell.2006.11.001.

Abstract

Metastasis occurs when genetically unstable cancer cells adapt to a tissue microenvironment that is distant from the primary tumor. This process involves both the selection of traits that are advantageous to cancer cells and the concomitant recruitment of traits in the tumor stroma that accommodate invasion by metastatic cells. Recent conceptual and technological advances promote our understanding of the origins and nature of cancer metastasis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Basement Membrane / pathology
  • Evolution, Molecular
  • Humans
  • Neoplasm Metastasis / pathology*
  • Neoplasms / pathology*
  • Neoplastic Cells, Circulating / pathology
  • Phenotype