Myeloid C-type lectins in innate immunity

Nat Immunol. 2006 Dec;7(12):1258-65. doi: 10.1038/ni1417.


C-type lectins expressed on myeloid cells comprise a family of proteins that share a common structural motif, and some act as receptors in pathogen recognition. But just as the presence of leucine-rich repeats alone is not sufficient to define a Toll-like receptor, the characterization of C-type lectin receptors in innate immunity requires the identification of accompanying signaling motifs. Here we focus on the known signaling pathways of myeloid C-type lectins and on their possible functions as autonomous activating or inhibitory receptors involved in innate responses to pathogens or self.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Immunity, Innate*
  • Infections / immunology*
  • Lectins, C-Type / immunology*
  • Receptors, Pattern Recognition / immunology


  • Lectins, C-Type
  • Receptors, Pattern Recognition