The TREM receptor family and signal integration

Nat Immunol. 2006 Dec;7(12):1266-73. doi: 10.1038/ni1411.


TREM proteins are a family of cell surface receptors that participate in diverse cell processes, including inflammation, bone homeostasis, neurological development and coagulation. TREM-1, the first to be identified, acts to amplify inflammation. Other TREM proteins regulate the differentiation and function of macrophages, microglia, dendritic cells, osteoclasts and platelets. Here we discuss the state of the field, putative ligands of TREM proteins and the challenges that remain in understanding TREM biology.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Membrane Glycoproteins / genetics
  • Membrane Glycoproteins / immunology*
  • Membrane Glycoproteins / metabolism
  • Models, Immunological*
  • Receptors, Immunologic / genetics
  • Receptors, Immunologic / immunology*
  • Receptors, Immunologic / metabolism
  • Signal Transduction / immunology*


  • Membrane Glycoproteins
  • Receptors, Immunologic