From antigen processing to peptide-MHC binding

Nat Immunol. 2006 Dec;7(12):1277-9. doi: 10.1038/ni1206-1277.


Emil R. Unanue recounts his seminal work 25 years ago demonstrating that antigens are phagocytosed and processed by antigen-presenting cells and that class II major histocompatibility complex molecules are peptide-binding proteins.

Publication types

  • Biography
  • Historical Article
  • Portrait

MeSH terms

  • Allergy and Immunology / history*
  • Animals
  • Antigen Presentation / immunology*
  • Antigen-Presenting Cells / immunology*
  • Antigen-Presenting Cells / metabolism
  • Histocompatibility Antigens Class II / immunology*
  • Histocompatibility Antigens Class II / metabolism
  • History, 20th Century
  • Humans


  • Histocompatibility Antigens Class II

Personal name as subject

  • Emile R Unanue