Diagnosis of lower limb deep venous thrombosis in emergency department patients: performance of Hamilton and modified Wells scores

Ann Emerg Med. 2006 Dec;48(6):678-85. doi: 10.1016/j.annemergmed.2006.04.010. Epub 2006 Jun 9.

Abstract

Study objective: We validate and compare the Hamilton score for assessment of lower limb deep venous thrombosis with the modified Wells score.

Methods: Consecutive patients presenting to the emergency department of a tertiary center for suspected lower limb deep venous thrombosis were prospectively recruited. Hamilton score and modified Wells score calculations, D-dimer, and complete (calf veins included), single lower limb ultrasonographic examination were performed for all patients. All patients with a negative ultrasonographic examination result for deep venous thrombosis were followed up for 3 months.

Results: The study population consisted of 116 men and 193 women, with an average age of 55.6 years (SD 20.1). A total of 67 (21.7%) patients were diagnosed with deep venous thrombosis. Forty (59.7%) of these patients had isolated calf deep venous thrombosis, and the other 27 (40.3%) patients had proximal deep venous thrombosis. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (LR+), and negative likelihood ratio (LR-) for an unlikely Hamilton score (score < or = 2) and D-dimer were 99% (95% confidence interval [CI] 92% to 99.96%), 42 % (95% CI 36% to 49%), 32% (95% CI 26% to 39%), 99% (95% CI 95% to 99.98%), 1.7 (95% CI 1.52% to 1.9%), and 0.04 (95% CI 0.01 to 0.25), respectively. The sensitivity, specificity, PPV, NPV, LR+ and LR- for an unlikely modified Wells score (score < or = 1) and D-dimer were 99% (95% CI 92% to 99.96%), 33 % (95% CI 27% to 39%), 29% (95% CI 23% to 35%), 99% (95% CI 93% to 99.97%), 1.47 (95% CI 1.34 to 1.62), and 0.05 (95% CI 0.01 to 0.32), respectively.

Conclusion: An unlikely probability of Hamilton score and a negative D-dimer may effectively exclude a lower limb deep venous thrombosis. Hamilton and modified Wells scores have similar performance characteristics.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Data Collection
  • Emergency Service, Hospital / statistics & numerical data*
  • Female
  • Fibrin Fibrinogen Degradation Products / metabolism
  • Humans
  • Male
  • Middle Aged
  • New Zealand
  • ROC Curve
  • Ultrasonography
  • Venous Thrombosis / diagnosis*
  • Venous Thrombosis / diagnostic imaging
  • Venous Thrombosis / therapy

Substances

  • Fibrin Fibrinogen Degradation Products
  • fibrin fragment D