Disease pathology: wasting energy fighting infection

Curr Biol. 2006 Nov 21;16(22):R964-5. doi: 10.1016/j.cub.2006.10.015.

Abstract

Drosophila melanogaster infected with Mycobacterium marinum suffer metabolic wasting similar to that seen in humans suffering from tuberculosis. This wasting is linked to insulin signaling and hastens host death.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Drosophila melanogaster / microbiology
  • Energy Metabolism / immunology
  • Energy Metabolism / physiology*
  • Humans
  • Insulin / metabolism*
  • Mycobacterium marinum*
  • Signal Transduction / physiology*
  • Tuberculosis / immunology
  • Tuberculosis / physiopathology*
  • Weight Loss

Substances

  • Insulin