MicroRNA modulation of RNA-binding protein regulatory elements

RNA Biol. 2006 Apr;3(2):57-9. doi: 10.4161/rna.3.2.3250. Epub 2006 Apr 1.

Abstract

We propose that microRNAs could modulate RNA-binding protein binding sites in a dynamic manner. We suggest that the cis-regulatory code targeted by microRNAs is, at least in part, the same as that read by mRNA-binding proteins. Our hypothesis predicts that microRNAs indirectly or directly bind to RNA-binding protein binding sites. Alternatively, the microRNA-mRNA interactions can themselves be the target of an mRNA-binding protein. Lastly, we envision examples where multiple mRNA regulatory elements are simultaneously influenced by microRNA-mRNA interactions such that the binding of one or more microRNA results in conformational changes in the structure of the mRNA, thereby, either revealing or masking a second regulatory element.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Humans
  • MicroRNAs*
  • Models, Biological
  • Models, Genetic
  • Nucleic Acid Conformation
  • RNA, Messenger / chemistry*
  • RNA, Untranslated / chemistry
  • RNA-Binding Proteins / chemistry*

Substances

  • MicroRNAs
  • RNA, Messenger
  • RNA, Untranslated
  • RNA-Binding Proteins