Inversion (11)(p15q22) with NUP98-DDX10 fusion gene in pediatric acute myeloid leukemia

Cancer Genet Cytogenet. 2006 Dec;171(2):122-5. doi: 10.1016/j.cancergencyto.2006.07.002.


The inv(11)(p15q22), a rare but recurrent chromosome abnormality that creates a NUP98-DDX10 fusion gene, is associated with de novo or secondary myeloid malignancies. We report a case of acute monocytic leukemia presenting this rearrangement, studied using fluorescence in situ hybridization (FISH) and reverse transcriptase-PCR (RT-PCR). We also review the cases of inv(11) associated with NUP98-DDX10 reported in the literature.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Child
  • Chromosome Inversion*
  • Chromosomes, Human, Pair 11 / genetics*
  • DEAD-box RNA Helicases / genetics*
  • Gene Fusion*
  • Humans
  • Leukemia, Myeloid, Acute / drug therapy
  • Leukemia, Myeloid, Acute / enzymology
  • Leukemia, Myeloid, Acute / genetics*
  • Male
  • Molecular Sequence Data
  • Nuclear Pore Complex Proteins / genetics*


  • Nuclear Pore Complex Proteins
  • Nup98 protein, human
  • DDX10 protein, human
  • DEAD-box RNA Helicases

Associated data

  • GENBANK/AB040537
  • GENBANK/AB040538