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, 95 (12), 1611-25

First International Consensus on the Methodology of Lymphangiogenesis Quantification in Solid Human Tumours

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First International Consensus on the Methodology of Lymphangiogenesis Quantification in Solid Human Tumours

I Van der Auwera et al. Br J Cancer.

Abstract

The lymphatic system is the primary pathway of metastasis for most human cancers. Recent research efforts in studying lymphangiogenesis have suggested the existence of a relationship between lymphatic vessel density and patient survival. However, current methodology of lymphangiogenesis quantification is still characterised by high intra- and interobserver variability. For the amount of lymphatic vessels in a tumour to be a clinically useful parameter, a reliable quantification technique needs to be developed. With this consensus report, we therefore would like to initiate discussion on the standardisation of the immunohistochemical method for lymphangiogenesis assessment.

Figures

Figure 1
Figure 1
Lymphangiogenic growth factors and their receptors.
Figure 2
Figure 2
Representation of lymphangiogenic markers on lymphatic endothelial cells.

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