Diabetic nephropathy: worldwide epidemic and effects of current treatment on natural history

Curr Diab Rep. 2006 Dec;6(6):479-83. doi: 10.1007/s11892-006-0083-y.


Diabetic nephropathy has become a worldwide epidemic, accounting for approximately one third of all cases of end-stage renal disease. With increasing prevalence of diabetes particularly in Asia, and a global prevalence of microalbuminuria of 39%, the problem is expected to grow. Improved management of diabetes aimed at improved glycemic control, to avoid initiation of diabetic nephropathy, and antihypertensive treatment blocking the renin-angiotensin system, to avoid its progression, need to be implemented, particularly in high-risk patients.

Publication types

  • Review

MeSH terms

  • Antihypertensive Agents / therapeutic use
  • Diabetes Mellitus, Type 1 / physiopathology
  • Diabetes Mellitus, Type 2 / physiopathology
  • Diabetic Nephropathies / epidemiology*
  • Diabetic Nephropathies / physiopathology
  • Diabetic Nephropathies / therapy
  • Humans
  • Hyperglycemia / prevention & control
  • Incidence
  • Kidney Failure, Chronic / epidemiology


  • Antihypertensive Agents