Insulin-like growth factor-II (IGF-II) and IGF binding proteins in human endometrium

Ann N Y Acad Sci. 1991;626:295-307. doi: 10.1111/j.1749-6632.1991.tb37924.x.


The insulin-like growth factor autocrine/paracrine system is believed to play a role in steroid-mediated endometrial differentiation. It is constituted of the mitogenic peptides (IGF-I and IGF-II), membrane receptors, and a family of high-affinity binding proteins (IGFBPs) that regulate the actions of the IGFs at their target cells. We have investigated expression of the mRNAs encoding the three major IGFBPs (IGFBP-1, IGFBP-2, and IGFBP-3) in human endometrium and have found, by Northern analysis, differential expression of all three mRNAs in secretory compared to proliferative endometrium, different steroidal milieux. IGF-II mRNAs were also detected in secretory endometrium. Finally, we found that human endometrial stromal cells in culture synthesize and secrete IGFBP-2 and IGFBP-3, and that the synthesis of IGFBP-2 is regulated by steroid hormones.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Autoradiography
  • Blotting, Northern
  • Blotting, Western
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism*
  • Cells, Cultured
  • Endometrium / cytology
  • Endometrium / metabolism*
  • Female
  • Humans
  • Insulin-Like Growth Factor Binding Proteins
  • Insulin-Like Growth Factor II / genetics
  • Insulin-Like Growth Factor II / metabolism*
  • Precipitin Tests
  • RNA, Messenger / metabolism
  • Somatomedins / metabolism


  • Carrier Proteins
  • Insulin-Like Growth Factor Binding Proteins
  • RNA, Messenger
  • Somatomedins
  • Insulin-Like Growth Factor II