Sleep in schizophrenia: impairments, correlates, and treatment

Psychiatr Clin North Am. 2006 Dec;29(4):1033-45; abstract ix-x. doi: 10.1016/j.psc.2006.08.002.


In untreated schizophrenia, psychotic decompensation is associated with profound insomnia, one of the prodromal symptoms associated with psychotic relapse. First- and second-generation antipsychotic medication can ameliorate this insomnia, but side effects may include sedation or residual insomnia. Patients who are clinically stable and medicated may continue to experience disturbed sleep, including long sleep-onset latencies, poor sleep efficiency, slow wave sleep deficits, and short rapid eye movement latencies. Schizophrenia also can be associated with comorbid sleep disorders, which may be enhanced or induced by antipsychotic medication. Sleep disorders in schizophrenia should be treated vigorously because normalized sleep and its restorative processes may be essential for a positive clinical outcome.

Publication types

  • Review

MeSH terms

  • Antioxidants / therapeutic use*
  • Antipsychotic Agents / adverse effects
  • Antipsychotic Agents / therapeutic use*
  • Humans
  • Melatonin / therapeutic use*
  • Schizophrenia / drug therapy*
  • Sleep Wake Disorders / chemically induced
  • Sleep Wake Disorders / drug therapy*


  • Antioxidants
  • Antipsychotic Agents
  • Melatonin