Plasmodium falciparum: immunization with MSP1-42 induced non-inhibitory antibodies that have no blocking activities but enhanced the potency of inhibitory anti-MSP1-42 antibodies

Exp Parasitol. 2007 Apr;115(4):403-8. doi: 10.1016/j.exppara.2006.10.005. Epub 2006 Nov 21.


Hyperimmunization with Plasmodium falciparum MSP1-42 could induce antibodies that have little or no parasite growth inhibitory activities. These antisera had no blocking activities as determined by their ability to interfere with the in vitro activities of growth inhibitory anti-MSP1-42 sera. Equally important, they enhanced the potency of growth inhibitory anti-MSP1-42 sera.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Antibodies, Blocking / biosynthesis
  • Antibodies, Blocking / immunology
  • Antibodies, Protozoan / biosynthesis*
  • Antibodies, Protozoan / immunology*
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Immune Sera / immunology*
  • Immunoglobulin G / biosynthesis
  • Immunoglobulin G / immunology
  • Merozoite Surface Protein 1 / immunology*
  • Plasmodium falciparum / immunology*
  • Rabbits


  • Antibodies, Blocking
  • Antibodies, Protozoan
  • Immune Sera
  • Immunoglobulin G
  • Merozoite Surface Protein 1