Activation of 5-HT3 receptor by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens

Brain Res. 1991 Mar 15;543(2):354-7. doi: 10.1016/0006-8993(91)90050-6.

Abstract

The serotonin-3 (5-HT3) agonist 1-phenylbiguanide (0.1-1.0 mM in perfusate) caused a robust, dose-dependent enhancement of extracellular dopamine content in nucleus accumbens as measured by in vivo microdialysis. This action was antagonized by co-perfusion of the 5-HT3 antagonists zacopride and GR38032F (1 mM in perfusate). Similar effects were observed in 5-HT-denervated rats. These findings suggest that there is a potent modulation of dopamine (DA) release in the nucleus accumbens mediated via 5-HT3 receptors, which appear to be located presynaptically on DA terminals of the mesolimbic DA pathway.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3,4-Dihydroxyphenylacetic Acid / metabolism
  • 5,7-Dihydroxytryptamine / pharmacology
  • Animals
  • Benzamides / pharmacology
  • Biguanides / pharmacology*
  • Brain Chemistry / drug effects
  • Bridged Bicyclo Compounds / pharmacology
  • Bridged Bicyclo Compounds, Heterocyclic*
  • Denervation
  • Dopamine / metabolism*
  • Homovanillic Acid / metabolism
  • Hydroxyindoleacetic Acid / metabolism
  • Hypoglycemic Agents / pharmacology*
  • Imidazoles / pharmacology
  • In Vitro Techniques
  • Male
  • Nucleus Accumbens / drug effects
  • Nucleus Accumbens / metabolism*
  • Ondansetron
  • Rats
  • Rats, Inbred Strains
  • Receptors, Serotonin / drug effects*
  • Serotonin Antagonists / pharmacology

Substances

  • Benzamides
  • Biguanides
  • Bridged Bicyclo Compounds
  • Bridged Bicyclo Compounds, Heterocyclic
  • Hypoglycemic Agents
  • Imidazoles
  • Receptors, Serotonin
  • Serotonin Antagonists
  • 3,4-Dihydroxyphenylacetic Acid
  • 5,7-Dihydroxytryptamine
  • Ondansetron
  • Hydroxyindoleacetic Acid
  • zacopride
  • Dopamine
  • phenyl biguanide
  • Homovanillic Acid