From miso, saké and shoyu to cosmetics: a century of science for kojic acid

Nat Prod Rep. 2006 Dec;23(6):1046-62. doi: 10.1039/b603758p. Epub 2006 Oct 18.

Abstract

This article reviews the curious history of kojic acid, discovered as a fungal natural product in 1907. It was one of the first secondary metabolites to have its biosynthetic pathway studied by the isotope tracer technique, and, more recently, has been of interest as a skin lightening agent. There are 112 references.

Publication types

  • Review

MeSH terms

  • Aspergillus / metabolism*
  • Cosmetics* / chemistry
  • Cosmetics* / isolation & purification
  • Cosmetics* / pharmacology
  • Pyrones* / chemistry
  • Pyrones* / isolation & purification
  • Pyrones* / pharmacology
  • Skin / drug effects*
  • Soy Foods

Substances

  • Cosmetics
  • Pyrones
  • kojic acid