Histological findings in cerebellar tonsils of patients with Chiari type I malformation

Childs Nerv Syst. 2007 Apr;23(4):427-9. doi: 10.1007/s00381-006-0252-y. Epub 2006 Nov 22.

Abstract

Objectives: Cerebellar tonsillectomy is often performed for relief of symptoms associated with Chiari type I malformation (CMI). Nonetheless, the idea of removing supposedly healthy central nervous tissue has been a source of concern for neurosurgeons. The aim of this paper is to determine the histological changes in the cerebellar tonsils of patients with a wide range of symptoms and conditions related to CMI.

Materials and methods: The cerebellar tonsils of 43 pediatric patients with CMI were sent to pathology for histological examination.

Conclusion: The cerebellar tonsils in a great majority of CMI patients can be abnormal. We suggest that the reported histological findings are secondary to injury and ischemia.

MeSH terms

  • Adolescent
  • Adult
  • Arnold-Chiari Malformation / complications*
  • Arnold-Chiari Malformation / pathology*
  • Cerebellar Diseases / complications*
  • Cerebellar Diseases / pathology*
  • Child
  • Child, Preschool
  • Female
  • Histological Techniques / methods
  • Humans
  • Infant
  • Male