Fine-mapping the putative chromosome 17q21-22 prostate cancer susceptibility gene to a 10 cM region based on linkage analysis

Hum Genet. 2007 Mar;121(1):49-55. doi: 10.1007/s00439-006-0274-2. Epub 2006 Nov 21.


Prostate cancer linkage studies have suggested the existence of a prostate cancer susceptibility gene on chromosome 17q21-22. We now report the results of an extended linkage analysis including 95 new multiplex prostate cancer families and 9 additional microsatellite markers resulting in a maximum LOD score of 2.99 at approximately 81-82 cM for all 453 pedigrees. Results from these 95 new pedigrees provide additional support for a chromosome 17q21-22 prostate cancer susceptibility gene. Inclusion of the 9 additional markers significantly reduced the size of the candidate region, as defined using a 1-LOD support interval, especially when focusing analyses on subsets of pedigrees with four or more confirmed affecteds or average age of diagnosis less than or equal to 65 years. A novel subset analysis of only those families (n = 147) that had four or more prostate cancer cases and an average age of prostate cancer diagnosis < or = 65 years results in a maximum LOD score of 5.49 at 78 cM with a 1-LOD support interval of 10 cM. This large set of pedigrees with four more prostate cancer cases characterized by early-onset disease will serve as a useful resource for identifying the putative 17q21-22 prostate cancer susceptibility gene.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Age of Onset
  • Aged
  • Chromosome Mapping*
  • Chromosomes, Human, Pair 17*
  • Genetic Linkage*
  • Genetic Predisposition to Disease*
  • Humans
  • Lod Score
  • Male
  • Prostatic Neoplasms / diagnosis
  • Prostatic Neoplasms / genetics*