Antimicrobial prophylaxis to prevent surgical site infections in a rural sub-Saharan hospital

Clin Microbiol Infect. 2006 Dec;12(12):1224-7. doi: 10.1111/j.1469-0691.2006.01551.x.

Abstract

A prospective cohort study was performed to collect baseline data concerning surgical site infections (SSIs) and antimicrobial prophylaxis (AMP) in a remote sub-Saharan district hospital. The SSI rate of 22% was high. Most (88%) of the patients received prophylaxis after incision, and only 5% within the 30-min period before incision. Of all pathogens isolated from SSIs, 60% were resistant to the agent administered. The antibiotics given most frequently were chloramphenicol (60%), aminopenicillins (23%) and benzylpenicillin (15%). Staphylococcus aureus (36%), Escherichia coli (5%) and enterococci (4%) were the pathogens isolated most commonly from SSIs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / therapeutic use*
  • Antibiotic Prophylaxis*
  • Bacteria / drug effects
  • Bacteria / isolation & purification*
  • Cohort Studies
  • Drug Resistance, Bacterial
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Rural Health Services / statistics & numerical data
  • Surgical Wound Infection / microbiology*
  • Surgical Wound Infection / prevention & control*
  • Tanzania

Substances

  • Anti-Bacterial Agents