Synthesis of pyochelin-norfloxacin conjugates

Freddy Rivault; Clémence Liébert; Alain Burger; Françoise Hoegy; Mohamed A Abdallah; Isabelle J Schalk; Gaëtan L A Mislin

doi:10.1016/j.bmcl.2006.11.005

Synthesis of pyochelin-norfloxacin conjugates

Bioorg Med Chem Lett. 2007 Feb 1;17(3):640-4. doi: 10.1016/j.bmcl.2006.11.005. Epub 2006 Nov 6.

Authors

Freddy Rivault¹, Clémence Liébert, Alain Burger, Françoise Hoegy, Mohamed A Abdallah, Isabelle J Schalk, Gaëtan L A Mislin

Affiliation

¹ Métaux et Microorganismes: Chimie, Biologie et Applications, UMR 7175-LC1 Institut Gilbert Laustriat CNRS-Université Louis Pasteur (Strasbourg I), ESBS, Boulevard Sébastien Brant, F-67400 Illkirch, France.

PMID: 17123817
DOI: 10.1016/j.bmcl.2006.11.005

Abstract

Using synthetic functionalized analogues of pyochelin, a siderophore common to several pathogenic Pseudomonas and Burkholderia species, four fluoroquinolone-pyochelin conjugates were efficiently synthesized and evaluated for their biological activities.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / pharmacology*
Burkholderia cepacia / drug effects
Iron Chelating Agents / pharmacology
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Norfloxacin / chemistry*
Norfloxacin / pharmacology*
Phenols / chemistry*
Phenols / pharmacology*
Pseudomonas aeruginosa / drug effects
Structure-Activity Relationship
Thiazoles / chemistry*
Thiazoles / pharmacology*

Substances

Anti-Bacterial Agents
Iron Chelating Agents
Phenols
Thiazoles
pyochelin
Norfloxacin