Abstract
The synthesis and antiallergic activity of a series of novel thiophene-, pyrrole-, furan-, and benzenecarboxamidotetrazoles are described. A number of compounds inhibit the release of histamine from anti-IgE-stimulated human basophils. Optimal inhibition is exhibited in compounds with a 3-alkoxy, a 4-halo, and a 5-methyl, 5-methoxy, or 5-bromo on a thiophene-2-carboxamidotetrazole.
MeSH terms
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Basophils / drug effects
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Basophils / metabolism
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Benzene Derivatives / chemical synthesis*
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Benzene Derivatives / pharmacology
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Chemical Phenomena
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Chemistry
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Histamine H1 Antagonists / chemical synthesis*
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Histamine H1 Antagonists / pharmacology
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Histamine Release / drug effects
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Humans
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Pyrroles / chemical synthesis*
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Pyrroles / pharmacology
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Structure-Activity Relationship
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Tetrazoles / chemical synthesis*
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Tetrazoles / pharmacology
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Thiophenes / chemical synthesis*
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Thiophenes / pharmacology
Substances
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Benzene Derivatives
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Histamine H1 Antagonists
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Pyrroles
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Tetrazoles
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Thiophenes