Folic acid, homocysteine, and cardiovascular disease: judging causality in the face of inconclusive trial evidence

BMJ. 2006 Nov 25;333(7578):1114-7. doi: 10.1136/bmj.39000.486701.68.

Abstract

Increasing intake of folic acid would be a relatively cheap and simple way of reducing heart disease, if it works. Can we draw a definitive conclusion from the current evidence?

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / blood
  • Cardiovascular Diseases / prevention & control*
  • Causality
  • Cohort Studies
  • Evidence-Based Medicine
  • Folic Acid / administration & dosage*
  • Homocysteine / blood*
  • Homocystinuria / etiology
  • Humans
  • Polymorphism, Genetic
  • Randomized Controlled Trials as Topic

Substances

  • Homocysteine
  • Folic Acid